Pyruvate Kinase Deficiency

Pyruvate kinase (PK) deficiency is one of the most common enzymatic defects of the RBCs, it manifests clinically as a hemolytic anemia that can range from mild to severe. Pyruvate kinase (PK) deficiency is inherited in an autosomal recessive pattern. The birth history of patients with pyruvate kinase deficiency includes severe anemia, severe jaundice, kernicterus, and a history of exchange transfusion. […]
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