Category: Leukemias

Hypereosinophilic syndrome (HES) is a condition characterized by peripheral blood eosinophilia with manifestations of organ system involvement or dysfunction directly related to eosinophilia in the absence of parasitic, allergic, or other secondary causes of eosinophilia. The ICD 10 code for Hypereosinophilic syndrome [HES] is D72.119. Secondary eosinophilia is a cytokine-derived (interleukin-5 [IL-5]) reactive phenomenon. Worldwide, parasitic diseases are the most […]

Read more

Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. Large granular lymphocytic leukemia is an uncommon condition also described as CD8 lymphocytosis with neutropenia or T-lymphoproliferative disease. Peripheral blood lymphocytosis comprises cells with round or oval nuclei with moderately condensed chromatin and rare […]

Read more

Hairy cell leukemia (HCL) is an indolent, low-grade, B-cell lymphoma characterized by the following: Circulating B-cells with cytoplasmic projections (“hairy” appearance). Splenomegaly. Absent lymphadenopathy. Pancytopenia. Monocytopenia. Hairy cell leukemia is relatively uncommon and accounts for 2% of all leukemia cases, which is about 600-800 new patients diagnosed each year in the USA. It has an extremely low incidence in Japan. The […]

Read more

Chronic Lymphocytic Leukemia (CLL) is a low-grade lymphoproliferative malignancy in which there is a proliferation of small mature lymphocytes (almost always B cells) in the blood, bone marrow, spleen, and lymph nodes. CLL is the most common type of leukemia in the Western world. The ICD-10 code for CLL is C91.1. Clinical Features: CLL occurs mainly in the elderly; 75% […]

Read more

Acute Myeloid Leukemia (AML) is a malignant proliferation of myeloblasts in the blood and bone marrow. The hematopoietic precursors are arrested in an early stage of development. Most AML subtypes are distinguished from other related blood disorders by the presence of more than 20% blasts in the bone marrow. The disease is commonest in the middle-aged and elderly. The ICD-10 code […]

Read more

Acute Lymphoblastic Leukemia (ALL) is a malignant proliferation of lymphoblasts in the blood and bone marrow. The disease is usually rapidly progressive if untreated. The incidence of ALL peaks in childhood and then remains relatively constant at lower levels throughout adult life. Two-thirds of all ALL cases occur in children, with a peak incidence at age 2 to 5 years; […]

Read more