Miscellaneous Red Cell Abnormalities

Introduction Adult human bone marrow synthesizes 4 X 1014 molecules of hemoglobin every second. Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments—mitochondria and cytoplasm, respectively—and then combined in cytoplasm in an amazingly accurate manner. Four major problems can manifest during this delicate process: Qualitative defects of globin chain synthesis result in hemoglobinopathies such as […]

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