Castleman Disease

Castleman Disease - Cervical Lymphadenopathy

What is Castleman Disease? Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It was first described by Dr. Benjamin Castleman in the 1950s. It is also known as Castleman’s disease, giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). Castleman disease is not cancer. Instead, it is called a nonclonal lymphoproliferative disorder. This means there […]

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Waldenström’s Macroglobulinemia

Waldenström's Macroglobulinemia

Waldenström’s macroglobulinemia (WM), also known as Lymphoplasmacytic Lymphoma is an indolent B-cell malignancy in which there is a proliferation of small lymphocytes with some plasmacytoid differentiation. The disease is clinically more similar to a lymphomatous disease than to myeloma and other plasma cell disorders. Waldenström macroglobulinemia is one of the malignant Monoclonal Gammopathies. There is usually massive production of monoclonal IgM. […]

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Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphomas (NHL) are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the GI tract. Most Non-Hodgkin lymphomas (NHL) are B-cell neoplasms though occasionally they are of T-cell lineage. These tumors may result from chromosomal translocations, infections, environmental factors, immunodeficiency states, and chronic […]

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Hodgkin’s Disease

PET Scan

Hodgkin’s Disease (Hodgkin Lymphoma) is a malignant neoplasm that usually arises in a lymph node. It results from the clonal transformation of cells of B-cell origin, giving rise to pathognomonic binucleated Reed-Sternberg cells (RS cells). The nature of the malignant RS cell remains uncertain. Clonally integrated Epstein-Barr virus is present in the RS cells in about 40% of cases. The cause […]

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