Sickle Cell Disease

Sickle cell disease (HbS) is a severe hereditary form of anemia in which a mutated form of hemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent. In this disease, a single base mutation in the β-globin gene leads to the substitution of valine for glutamine at the 6th […]

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