Tumor Lysis Syndrome

TLS

Tumor lysis syndrome (TLS) refers to the metabolic disturbances that occur when large numbers of neoplastic cells are killed rapidly, leading to the release of intracellular ions and metabolic byproducts into the systemic circulation. These electrolyte and metabolic disturbances can progress to clinical toxic effects, including renal insufficiency, cardiac arrhythmias, seizures, and death due to multiorgan failure. The tumor lysis syndrome […]

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Chemotherapeutic Agents

Chemotherapeutic Agents

The purpose of this article is to review the basic principles for the safe and effective use of various chemotherapeutic agents in the treatment of neoplastic diseases. Introduction: The long-term understanding of cancer growth is that it is a net result of uncontrolled multiplication of cells that out paces the rate of natural cell death (apoptosis) within the tumor mass. […]

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Principles of Cancer Therapy

Cancer Therapy

Curing cancer requires eliminating all cancer cells. The major modalities of therapy are: Surgery (for local and local-regional disease): Surgery is the removal of the tumor and surrounding tissue during an operation. A doctor who specializes in treating cancer using surgery is called a surgical oncologist. Surgery is the oldest type of cancer therapy and remains an effective treatment for many types […]

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