Ask Hematologist | Understand Hematology
Everything you need to know about blood disorders
Primary Myelofibrosis (PMF) is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped RBCs. The spleen is often very large. Myelofibrosis may be primary or secondary to a number of hematologic, malignant, and nonmalignant conditions e.g. PRV, ET, hairy cell leukemia, cancer with bone marrow metastases, osteomyelitis and TB. PMF is more common than […]
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Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) characterized by megakaryocyte hyperplasia and thrombocytosis due to a clonal abnormality of a multipotent hematopoietic stem cell. From the genetic perspective, ET patients harbour mutations in JAK2 (50–60%), CALR (15–30%) and MPL (1–5%) genes. Platelet survival is normal in ET. Approximately one-third of patients with ET are asymptomatic at diagnosis. ET usually occurs […]
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Polycythemia Rubra Vera (PRV) or Primary Polycythemia Vera is a chronic myeloproliferative disorder characterized by an increase in RBC mass, which often manifests as an increased hematocrit (Hct). There is a malignant transformation of the multipotential stem cell with excess production of red cells. PRV involves increased production of all cell lines, including RBCs, WBCs, and platelets. Polycythaemia Rubra Vera […]
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Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. Aetiology: In chronic myeloid leukemia (CML) there is a malignant transformation of the multipotential hematopoietic stem cells (pluripotent stem cells). There are excessive cells in the granulocytic series, primarily in […]
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