Prepare for MRCP Examination

Prepare for MRCP Examination.

How to prepare for the MRCP Examination? To prepare for part 1 of the MRCP examination, you must have a solid knowledge of internal medicine, including hematology, hemato-oncology, and genetics, along with expert insights. This article will cover the hematology and hemato-oncology topics relevant to part 1 of the UK MRCP examination. What is the MRCP examination? The Membership of […]

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Hypereosinophilic Syndrome

Hypereosinophilic Syndrome

Hypereosinophilic syndrome (HES) is a condition characterized by peripheral blood eosinophilia with manifestations of organ system involvement or dysfunction directly related to eosinophilia in the absence of parasitic, allergic, or other secondary causes of eosinophilia. Secondary eosinophilia is a cytokine-derived (interleukin-5 [IL-5]) reactive phenomenon. Worldwide, parasitic diseases are the most common cause, whereas, in developed countries, allergic diseases are the […]

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Vascular Bleeding Disorders

Ehlers-Danlos Syndrome

Bleeding may result from abnormalities in Platelets Coagulation factors Blood vessels Vascular bleeding disorders result from defects in blood vessels, typically causing petechiae, purpura, and bruising but, except for hereditary hemorrhagic telangiectasia, seldom leading to serious blood loss. Bleeding may result from deficiencies of vascular and perivascular collagen in Ehlers-Danlos syndrome and in other rare hereditary connective tissue disorders (e.g. […]

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CAR T-Cell Therapy

CAR-T Cell Therapy

The mechanism of action of CAR T-cell therapy: T cells: To understand CAR T-cell therapy, it helps to understand what T cells do. White blood cells called lymphocytes play an important part in fighting infection and diseases, including cancer. There are different types of lymphocytes. T cells are one type. T cells move around the body to find and destroy defective […]

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Coronavirus and Blood

Coronavirus and Blood

Coronavirus and Blood: Does coronavirus have direct effects on Blood? The United States and countries around the world face a major public health concern with the current outbreak of the novel (new) coronavirus (COVID-19). The emergence of the novel coronavirus outbreak in December 2019 was followed by its spread on a global scale unparalleled in the last 100 years. At […]

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Abnormal Hemoglobins

Abnormal Hemoglobins

Hemoglobin is a carrier for oxygen from the lungs to the various tissues and carbon dioxide from other parts of the body to the lungs. About 70% of the body’s iron is present in the red blood cells in the form of hemoglobin. Hemoglobin is an iron-protein complex that gives red blood cells its red color. It is made up of […]

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Approach to Lymphocytosis

Approach to Lymphocytosis

Diagnostic Approach to Lymphocytosis:  Lymphocytes are white blood cells that serve primarily as the body’s adaptive immune system and provide humoral or cell-mediated immunity against a variety of bacterial, viral, or other pathogens. They are comprised mainly of T, B, and natural killer (NK) cells, and the body typically maintains the absolute lymphocyte count (ALC) in a range of fewer […]

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Nutrition and Blood

nutrition and blood

Nutrition and Blood: Nutrition plays a crucial role in maintaining optimal blood health, as it provides essential nutrients necessary for the production and function of blood cells, the regulation of blood clotting, and the maintenance of overall circulatory health. This article aims to provide a comprehensive review of the relationship between nutrition and blood health, highlighting key nutrients, their sources, […]

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Systemic Mastocytosis

Urticaria Pigmentosa

Systemic mastocytosis (SM) is a form of mastocytosis in which mast cells accumulate in internal tissues and organs such as the liver, spleen, bone marrow, and small intestines. It is typically diagnosed in adults. Signs and symptoms vary based on which parts of the body are affected. The ICD-10 code for systemic mastocytosis is “D47.02“. To keep us healthy, mast […]

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Erythropoiesis Stimulating Medicines

EPO

Erythropoiesis stimulating agents (ESAs) are man-made versions of Erythropoietin (EPO), which is a hormone (chemical messenger) produced naturally by the kidneys. Erythropoietin is produced to a lesser extent by the liver. Only about 10% of erythropoietin is produced in the liver. The erythropoietin gene has been found on human chromosome 7 (band 7q21). The role of erythropoietin is to stimulate the bone […]

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