Erythropoiesis Stimulating Medicines

EPO

Erythropoiesis stimulating agents (ESAs) are man-made versions of Erythropoietin (EPO), which is a hormone (chemical messenger) produced naturally by the kidneys. Erythropoietin is produced to a lesser extent by the liver. Only about 10% of erythropoietin is produced in the liver. The erythropoietin gene has been found on human chromosome 7 (band 7q21). The role of erythropoietin is to stimulate the bone […]

Read more

Surgery and Hemostasis

Perioperative Complications

What is Hemostasis? Hemostasis is the process of how the body stops bleeding from a cut or injury. This involves forming a clot to close the hole in the blood vessel and repairing the blood vessel. When a blood vessel is injured, platelets stick together to form a plug. Proteins, called clotting factors, interact to form a fibrin mesh to […]

Read more

Pediatric Hematology

Pediatric Hematology

Pediatric hematology has emerged as a specialized science with age-specific reference ranges that correlate with the hematopoietic, immunologic and chemical changes in a developing child. A newborn represents the culmination of developmental events from conception and implantation through organogenesis. The embryo requires red cells for the transport of maternal oxygen to permit this growth and development. Birth brings dramatic changes […]

Read more

Amyloidosis

Introduction: Amyloidosis is the name for a group of rare, serious conditions caused by a build-up of amyloid in organs and tissues throughout the body. Amyloid is an abnormal insoluble protein that is produced in the bone marrow and can be deposited in any tissue or organ. The build-up of the amyloid proteins (deposits) can make it difficult for the […]

Read more

New Oral Anticoagulants

Apixaban

The NOACs are new oral anticoagulants, or sometimes called non-vitamin K antagonist (VKA) oral anticoagulants (since they are no longer that new). Oral anticoagulants are widely used for long-term prevention and treatment of venous and arterial thromboembolism. Until recently, vitamin K antagonists, such as warfarin, were the only available oral anticoagulants. This situation changed with the recent introduction of the […]

Read more

Antiphospholipid Syndrome

Antiphospholipid Syndrome

Antiphospholipid antibody syndrome (APS) is an autoimmune disorder in which patients have autoantibodies to phospholipid-bound proteins (eg, beta2-glycoprotein I, prothrombin, annexin A5). The pathophysiology is not precisely known. Antiphospholipid Syndrome (APS) is an important recognised cause of acquired treatable thrombophilia. It is characterised by the core clinical manifestations of thrombosis in both venous and arterial circulation resulting in recurrent thrombotic […]

Read more

Castleman Disease

Castleman Disease - Cervical Lymphadenopathy

What is Castleman Disease? Castleman disease (CD) is a rare disease of lymph nodes and related tissues. It was first described by Dr. Benjamin Castleman in the 1950s. It is also known as Castleman’s disease, giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). Castleman disease is not cancer. Instead, it is called a nonclonal lymphoproliferative disorder. This means there […]

Read more

Clinical Trials

Clinical Research

Clinical research is medical research involving people. There are two types, clinical studies, and clinical trials. Clinical studies (sometimes called observational studies) observe people in normal settings. Researchers gather information, group volunteers according to broad characteristics, and compare changes over time. For example, researchers may collect data through medical exams, tests, or questionnaires about a group of older adults over […]

Read more

Common Hematology Tests

Common Hematology Tests

Hematology is the study of blood and blood disorders. This article will explain some of the more common hematology tests and what purpose they serve. Hematology tests include tests on the blood, blood proteins and blood-producing organs. Hematological tests can help diagnose anemia, infection, hemophilia, blood-clotting disorders, and leukemia. The components of human blood include: Plasma. This is the liquid component of […]

Read more

Tumor Immunology

Tumor Immunology

Tumor immunology describes the interaction between cells of the immune system with tumor cells. Understanding the role of the immune system in the progression and development of cancer is important for the development of new therapies for cancer treatment. Tumor Antigens: The question of whether human tumors express antigens that can be recognized by the immune system has been answered with a resounding […]

Read more
1 2 3 9