Thalassemias are inherited disorders in which there is an abnormality of one or more of the globin genes leading to reduced globin protein production. There is, therefore, an imbalance of ß:α globin chain synthesis leading to globin chain precipitation, ineffective erythropoiesis and hemolysis. The hemoglobin molecule is a tetramer consisting of 4 polypeptide chains, known as globins, which are usually: 2 […]

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