Qualitative Platelet Disorders

Qualitative Platelet Disorders

Qualitative platelet disorders are suggested by a prolonged bleeding time (abnormal platelet function screen) or clinical evidence of bleeding in the setting of a normal platelet count and coagulation studies. They are most commonly acquired, but can be inherited. Platelet function testing with light transmission aggregometry (LTA), the platelet function analyzer (PFA-100), or a template bleeding time may reveal abnormalities […]

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Thrombocytopenia

Thrombocytopenia

The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days.¬†About one third are always transiently sequestered in the spleen. Platelets are eventually destroyed by apoptosis, a process independent […]

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