Stomatocytosis

Stomatocytosis

Stomatocytes (RBCs with slit-like central pallor)

Stomatocytosis is a rare condition of RBCs in which a mouthlike or slitlike pattern replaces the normal central zone of pallor. These cells are associated with congenital and acquired hemolytic anemia. The symptoms result from the anemia.

Stomatocytes are erythrocytes with a central slit or stoma instead of a circular area of pallor when examined on dried smears; they are uniconcave rather than biconcave, giving them a bowl-like appearance. A few stomatocytes may be observed in blood smears prepared from normal individuals, as well as from patients with acute alcoholism and hepatobiliary disease. Large numbers of stomatocytes are associated with very rare hereditary disorders of red cell cation permeability leading to increased or decreased red cell water content.

Hereditary Stomatocytosis comprises two different diseases: the xerocytosis or dehydrated hereditary stomatocytosis and the overhydrated hereditary stomatocytosis. Both are genetic disorders mainly due to an abnormality of red cell membrane permeability to monovalent cations (Na+ and K+) resulting in an alteration in the red blood cell water content. The movement of divalent cations and anions is normal. Typical red blood cells are known as stomatocytes (mouth featured cells) appear in blood smear examination. The clinical manifestation can vary from asymptomatic to severe hemolytic anemia. Hereditary Stomatocytosis shows autosomal dominant inheritance and may cause severe hemolytic anemia presenting very early in life.

Hemolytic anemia with stomatocytosis (up to 40–60%), elevated reticulocyte count, elevated serum bilirubin levels, and reduced serum haptoglobin concentration in children or adolescents are characteristic features of hereditary stomatocytosis.

Stomatocytes

Stomatocytes

Stomatocytes have been noted in diverse acquired conditions, including neoplasms, cardiovascular and chronic liver disease, alcoholism, and therapy with drugs, some of which are known to be stomatocytogenic in vitro. In some of these conditions, the percentage of stomatocytes on the peripheral blood smear can approach 100%. However, the clinical significance of this observation is unclear because stomatocytes are absent in most patients with the conditions listed. Furthermore, some stomatocytes can be found in normal individuals (3–5%). The most consistent association is that of stomatocytosis and heavy alcohol consumption.

Splenectomy ameliorates anemia in some cases.

Acquired stomatocytosis with hemolytic anemia occurs primarily with recent excessive alcohol ingestion. Stomatocytes in the peripheral blood and hemolysis disappear within 2 weeks of alcohol withdrawal. Stomatocytosis could also be seen in thalassemia, neoplastic, cardiovascular or hepatobiliary disease including acute alcoholism and during therapy with certain drugs some of which are known to be stomatocytogenic in vitro.

References:

Patrick G. Gallagher; Faramarz Naeim; and Bertil Glader. Red Blood Cell Membrane Disorders. https://www.sciencedirect.com/science/article/pii/B9780123838346000768

Summary
Stomatocytosis
Article Name
Stomatocytosis
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Stomatocytosis is a rare condition of RBCs in which a mouthlike or slitlike pattern replaces the normal central zone of pallor.
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askhematologist.com
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4 comments

  • Avatar Patricia Hanley

    How do they test for for Stomatocytosis? My 25 year old daughter has a chronic illness Endometriosis stage 4( which has not got the amount of research it should) and she has symptoms of Anemia.. Her hematocrit is 32.5 and hemoglobin is 10.5 and her latest blood test says Stomatocytes are present but no percentage. Most doctors want to blame everything on her Endometriosis but anemia is not a symptom. So we just want to make sure we arent missing anything. Thank you for any information or advice.

    • Hi Patricia,
      Stomatocytes are identified on the blood smear and can be seen in a variety of medical conditions especially liver disease and excess alcohol consumption. I don’t think there is a direct link between endometriosis and stomatocytosis. Anemia associated with endometriosis could be secondary to iron deficiency caused by heavy periods.
      BW,

  • Avatar Michele Carter

    I have had various blood tests and a blood smear test said occasional target cells. Image result for Stomatocytes
    Stomatocytes and elliptocytes present. Can you cause this to happen if you work too much, dont sleep enough, or are stressed or dont eat properly, why is my blood test showing this please and what does it mean for me? can it go and turn to a normal blood test again. I dont drink or smoke. Thank you. Michele

    • Hi Michele,
      Thank you for your comment.
      Some stomatocytes and elliptocytes can be seen in normal individuals and they don’t have any clinical significance as long as you are not anemic or having chronic liver disease. You can simply ignore them.
      BW,

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