Hemolytic Disease Of The Newborn (HDN)
Hemolytic disease of the newborn (HDN) is an alloimmune condition in which maternal IgG antibodies cross the placenta and destroy fetal red blood cells, leading to fetal anemia, hydrops fetalis, jaundice and, historically, significant neonatal mortality. Although the condition was first documented as early as 1609, its true mechanism remained unknown for centuries until the 1950s, when researchers clarified […]
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