Sickle Cell Disease
Sickle cell disease (SCD) is a hereditary hemoglobinopathy caused by a point mutation in the β-globin gene, resulting in the production of hemoglobin S (HbS). This abnormal hemoglobin polymerizes under low–oxygen conditions, distorting red blood cells into rigid, crescent-shaped “sickle” forms. Sickle cell disease is most prevalent among individuals of African descent, although it also affects populations in the Middle […]
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