Erythropoiesis Stimulating Medicines
Erythropoiesis-stimulating medicines (ESAs) are synthetic forms of erythropoietin, a natural hormone produced primarily by the kidneys and, to a lesser extent, by the liver. The erythropoietin gene, located on chromosome 7 (7q21), regulates the production of red blood cells (RBCs) in the bone marrow. When oxygen levels fall, the kidney’s peritubular interstitial cells release erythropoietin, which stimulates erythroid progenitor cells […]
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