Ask Hematologist | Understand Hematology
Everything you need to know about blood disorders
Many cancers may infiltrate the bone marrow, most common are carcinoma of the lung, breast, prostate, colon, and thyroid. In adults, malignant infiltration of bone marrow is most often seen in carcinomas of the prostate, breast, and lung, although any tumor that gives rise to blood borne metastases may infiltrate the marrow. In children, malignant infiltration of bone marrow is […]
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Cold agglutinin disease (CAD) is a rare disorder affecting 15% of patients with autoimmune hemolytic anemia (AIHA). The disease is defined by the presence of cold agglutinins (autoantibodies which are active at temperatures below 30°C). Cold agglutinins cause red blood cells to clump together (agglutinate) at low temperatures. Cold agglutinin disease (CAD) occurs more frequently after the age of 55. Clinical […]
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Cryoglobulins are single or mixed immunoglobulins which precipitate when they are exposed to cold and dissolve when warmed. They may be present in small quantities in the blood of some healthy people but are most frequently associated with abnormal protein production in a variety of diseases and conditions. Precipitated cryoglobulins can slow the flow of blood and block small blood vessels. This should […]
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Waldenström’s macroglobulinemia (WM), also known as Lymphoplasmacytic Lymphoma is an indolent B-cell malignancy in which there is a proliferation of small lymphocytes with some plasmacytoid differentiation. This rare form of blood cancer is characterized by an excess of abnormal white blood cells called lymphoplasmacytic cells in the bone marrow and overproduction of a protein called IgM. Waldenström’s macroglobulinemia is clinically more […]
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