Lupus Erythematosus (LE) Cells

LE Cell

Lupus Erythematosus (LE) Cells are neutrophils that have engulfed lymphocyte nuclei coated with and denatured by antibody to nucleoprotein. These cells were first described by Dr. Robert H. Heitzman in 1948, and they play a significant role in diagnosing systemic lupus erythematosus (SLE). The Lupus Erythematosus (LE) cell was so termed because of its exclusive presence in the bone marrow […]

Read more

Pelger-Huët Anomaly

Pelger-Huet anomaly

Pelger-Huët Anomaly (PHA) is a rare inherited blood disorder that affects the shape and function of white blood cells (WBCs). Pelger-Huët Anomaly is characterized by abnormal nuclear segmentation of neutrophils and other granulocytes, resulting in a bilobed or peanut-shaped nucleus instead of the normal trilobed shape. Although PHA is usually asymptomatic and benign, it can sometimes be associated with other […]

Read more

Leishmaniasis

Cutaneous Leishmaniasis

Leishmaniasis is a disease caused by an intracellular protozoan parasite (genus Leishmania) transmitted by the bite of a sand fly. The disease is present in scattered areas worldwide. Human infection is caused by 20 Leishmania species that are morphologically indistinguishable but can be differentiated by laboratory analysis. Leishmania promastigotes are transmitted by sand flies to vertebrate hosts. The clinical spectrum of […]

Read more

Lymphatic Filariasis

Elephantiasis

Lymphatic filariasis, considered globally as a neglected tropical disease (NTD), is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body’s fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes. People with the disease can suffer from lymphedema and elephantiasis and […]

Read more

Trypanosomiasis

Sleeping Sickness

Trypanosomiasis, also known as sleeping sickness, is a parasitic disease caused by Trypanosoma parasites transmitted to humans and animals through the bite of infected tsetse flies. Two types of trypanosomiasis affect humans: American trypanosomiasis, also known as Chagas disease, affects millions of people throughout the Americas. Carlos Chagas first described this disease in 1911 when he discovered the parasite in […]

Read more

Malaria

Malaria

Malaria is due to infection with specific protozoa of the Plasmodium genus. It is transmitted by the bite of an infective female Anopheles mosquito. The malaria parasite undergoes a single sexual cycle in the mosquito and recurrent asexual cycles, with the production of sexual forms (gametocytes) in man. Clinical features: The initial incubation period of malaria is 9-11 days. Malaria symptoms include […]

Read more

Human Immunodeficiency Virus

Kaposi Sarcoma

Human Immunodeficiency Virus (HIV) remains a global health challenge with significant implications for individuals, communities, and healthcare systems. HIV, a retrovirus primarily targeting the immune system, substantially threatens public health worldwide. Infection by the Human Immunodeficiency Virus (HIV) first appears as a transient flu-like illness. There then follows a variable period of good health, which may last many years. HIV has […]

Read more

Infectious Mononucleosis

Infectious Mononucleosis-Skin Rash

Infectious Mononucleosis (Glandular Fever), also known as mono, is due to infection by the Ebstein-Barr herpes Virus (EBV). Background: The disease was first described in the 1920s. The virus spreads through saliva, which is why it’s sometimes called “kissing disease“. the incubation period for mono is four to eight weeks. Using contaminated items, such as drinking glasses or toothbrushes, can spread the […]

Read more

Miscellaneous Red Cell Abnormalities

Sideroblastic Anemia-Perls Reaction

Introduction In the chapter of Miscellaneous Red Cell Abnormalities, we will discuss some of the commonly seen red blood cell abnormalities. Adult human bone marrow synthesizes 4 X 1014 molecules of hemoglobin every second. Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments—mitochondria and cytoplasm, respectively—and then combined in the cytoplasm in an amazingly accurate manner. Four major […]

Read more
1 2